In collaboration with Payame Noor University and Iranian Chemical Science and Technologies Association
1H qNMR Approach for Estimation of a Toxic Compound N,N-Dimethylamine in Metformin Hydrochloride: An Equivalent Efficient Method over Reversed Phase Derivatization HPLC Method

Sibaprasad Sahoo; Nisarg H. Desai; Anil Bhatt; K. Shivramchandra; B.V. Kamath

Volume 2, Issue 2 , September 2015, , Pages 112-119

Abstract
  A rapid, specific and accurate proton quantitative Nuclear Magnetic Resonance spectroscopic (1H qNMR) and also a reversed phase derivatization HPLC method have been developed to quantify a toxic, UV-visible inactive and non-volatile impurity N,N-Dimethylamine hydrochloride (DMA∙HCl) in Metformin Hydrochloride ...  Read More