Fatemeh Moeinpour; Danial Moodi; Haleh Sarabi-Omoori; Zarrin Eshaghi
Abstract
The aim of the present study was to develop electrochemical sensors based on pencil graphite electrode modified with green-caped ZnO, CdO nano particles and potassium tetra chloroplatinate (II), for a simple and fast simultaneous microextraction and determination of Aspirin (ASA) and Ibuprofen (IBU). ...
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The aim of the present study was to develop electrochemical sensors based on pencil graphite electrode modified with green-caped ZnO, CdO nano particles and potassium tetra chloroplatinate (II), for a simple and fast simultaneous microextraction and determination of Aspirin (ASA) and Ibuprofen (IBU). The nanoparticles were initially synthesized by the use of four vegetable extracts including garlic, onion, green onion and cabbage. The fabricated nanoparticles and platinum were then deposited on the surface of a pencil graphite electrode and was used as a working electrode in a three electrodes system. The Taguchi experimental design was employed for investigating the effects different parameters. For this purpose, a Taguchi L16 orthogonal array (OA) design was applied and the results were confirmed by the ANOVA test. The electrochemical behavior of ASA and IBU at the modified electrodes, were studied. The calibration curves were linear in the range of 5.17to 134.0 µg.mL-1 and 3.13 to 231.0 µg.mL-1 for ASA and IBU respectively. The limits of detection for ASA and IBU was calculated to be 0.50 and 0.42 µg.mL-1 respectively. The modified sensor showed good performance for simultaneous analysis of ASA and IBU in biological and pharmaceutical samples.
Fatemeh Moeinpour; Zarrin Eshaghi
Volume 5, Issue 2 , September 2018, , Pages 9-16
Abstract
The aim of this work was indirect determination of anti-cancer drug capecitabine using complexation with platinum (IV) and determination by graphite furnace atomic absorption spectroscopy (GFAAS). For this aim at first, the complex of platinum with capecitabine was performed and the ratio of drug to ...
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The aim of this work was indirect determination of anti-cancer drug capecitabine using complexation with platinum (IV) and determination by graphite furnace atomic absorption spectroscopy (GFAAS). For this aim at first, the complex of platinum with capecitabine was performed and the ratio of drug to metal was evalutsd with several ways. In the all of these methods, the ligand to metal ratio of the Potassium hexachloroplatinate (IV) and capecitabine complex was found to be 2:1. The extraction process was carried out by the hollow fiber supported functionalized multiwalled carbon nanotubes/ polyurethane foam (fMWCNT/PUF) foam as the solid adsorbent in the solid phase microextraction mode. The amount of desorbed platinum ion has been indirectly used to measure the drug concentrations. Parameters affecting the hollow fiber-solid phase microextraction (HF-SPME) such as pH of the donor phase, donor phase volume, the sorbent type and desorption solvent were optimized. Calibration graph was plotted and a curve with a linear response range of the 3.32 to 98.17 µg mL -1 and a detection limit 0.38 µg mL -1 was obtained.
