Parvin Pourhakkak; Mohammad Ali Karimi; Hossein Tavallali; Pouran Pourhakkak; Mohammad Mazloum Ardakani
Abstract
A new potentiometric sensor based on a β- cyclodextrin modified carbon paste electrode (CPE) was designed for the determination of the captopril drug. The effect of various cyclodextrins (α, β and γ- cyclodextrins) and their percentage, binder agent and ion additive on the potential ...
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A new potentiometric sensor based on a β- cyclodextrin modified carbon paste electrode (CPE) was designed for the determination of the captopril drug. The effect of various cyclodextrins (α, β and γ- cyclodextrins) and their percentage, binder agent and ion additive on the potential response have been investigated and the electrode with the best potential response was found. The linear concentration range for this electrode was 7.0×10-7-1.0×10-1 M with a low detection limit of 2.0 × 10-7 M. The effect of pH and temperature on the Nernstian slope was also investigated and the optimal range was obtained. The selectivity of the captopril CPE to interfering species including Li+, K+, Ni+, Mg2+, Ca2+, Co2+, Cr2+, Cr3+, Zn2+,Mn2+, Fe2+, F-, Cl-, SO42-, C2O42- PO43-, C2O42-, ascorbic acid, uric acid, glucose, D-fructose and sucrose was determined by Separate Solution (SSM) and Matched Potential Method (MPM) methods. Finally, the proposed electrode was tested for measuring captopril in drug formulation, blood serum, and urine samples.
Mohammad Mazloum-Ardakani; Azimeh Mandegari; Alireza Khoshroo Khoshroo; Saeed Masoum; Hadi Kargar
Volume 3, Issue 2 , September 2016, , Pages 96-104
Abstract
In this work, response surface methodology in conjunction with central composite design for modeling and optimization of the influence of some process variables (polyvinyl chloride (F1), ionophore (F2), additive (F3) and plasticizer (F4) amounts), on the performance of polyvinyl chloride membrane lead ...
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In this work, response surface methodology in conjunction with central composite design for modeling and optimization of the influence of some process variables (polyvinyl chloride (F1), ionophore (F2), additive (F3) and plasticizer (F4) amounts), on the performance of polyvinyl chloride membrane lead (ІІ) ion-selective electrode is discussed. The slope of 29.1 ± 0.1 mV at the optimal amounts of polyvinyl chloride (0.0283 g), ionophore (0.0074 g), additive (0.002 g) and plasticizer (0.060 g) has been achieved. The electrode exhibited a linear potential response to lead (II) in the concentration range of 1.0 × 10-5 mol L-1 to 1.0 × 10-1 mol L-1 over pH range of 3.0 - 5.5. Greatly, the alternating current impedance technique was applied to investigate the response mechanism of the electrode. The results were obtained from electrochemical impedance spectroscopy shows a linear concentrations range of 1.0 × 10-6 mol L-1 to 1.0×10-1 mol L-1 and in comparison with potentiometry, the pH range increased to 2.5 − 6.0.
