Haleh Omoori Sarabi; Zarrin Eshaghi; Javad Feizy
Abstract
For the first time, hollow fiber-solid liquid phase microextraction (HF-SLPME) using multiwalled carbon nanotube- ion exchange polyurethane foam (MWCNT-PUFIX) as adsorbent along with graphite furnace atomic absorption spectrometry was used to extract and measure the anticancer drug cisplatin. In this ...
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For the first time, hollow fiber-solid liquid phase microextraction (HF-SLPME) using multiwalled carbon nanotube- ion exchange polyurethane foam (MWCNT-PUFIX) as adsorbent along with graphite furnace atomic absorption spectrometry was used to extract and measure the anticancer drug cisplatin. In this method, the nanocomposite dispersed in octanol, is located in the pores and lumen of a porous polypropylene hollow fiber, was used as the extracting phase, this method benefits from high selectivity, high sample purification and enrichment, and reducing the consumption of organic solvents. The major factors affecting the extraction efficiency were investigated. The validation of the method was assessed by linearity, limit of detection, and accuracy calculated as relative recovery percent. The calibration curve was constructed under the optimal conditions was linear in the range of 1.00-55.0 µg/mL and the detection limit was 0.5 µg/mL. This method was successfully used for analysis of biological samples and the obtained results showed that the method has good accuracy and precision.
Fatemeh Moeinpour; Zarrin Eshaghi
Volume 5, Issue 2 , September 2018, , Pages 9-16
Abstract
The aim of this work was indirect determination of anti-cancer drug capecitabine using complexation with platinum (IV) and determination by graphite furnace atomic absorption spectroscopy (GFAAS). For this aim at first, the complex of platinum with capecitabine was performed and the ratio of drug to ...
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The aim of this work was indirect determination of anti-cancer drug capecitabine using complexation with platinum (IV) and determination by graphite furnace atomic absorption spectroscopy (GFAAS). For this aim at first, the complex of platinum with capecitabine was performed and the ratio of drug to metal was evalutsd with several ways. In the all of these methods, the ligand to metal ratio of the Potassium hexachloroplatinate (IV) and capecitabine complex was found to be 2:1. The extraction process was carried out by the hollow fiber supported functionalized multiwalled carbon nanotubes/ polyurethane foam (fMWCNT/PUF) foam as the solid adsorbent in the solid phase microextraction mode. The amount of desorbed platinum ion has been indirectly used to measure the drug concentrations. Parameters affecting the hollow fiber-solid phase microextraction (HF-SPME) such as pH of the donor phase, donor phase volume, the sorbent type and desorption solvent were optimized. Calibration graph was plotted and a curve with a linear response range of the 3.32 to 98.17 µg mL -1 and a detection limit 0.38 µg mL -1 was obtained.