@article { author = {Baban Mohite, Popat and Gajanan Khanage, Shantaram and Shankar Jadhav, Sandip}, title = {Reversed Phase High Performance Liquid Chromatographic Method for Simultaneous Estimation of Eperisone Hydrochloride and Paracetamol in Tablet Dosage Form}, journal = {Iranian Journal of Analytical Chemistry}, volume = {2}, number = {1}, pages = {57-62}, year = {2015}, publisher = {Payame Noor University, Iran}, issn = {2383-2207}, eissn = {2538-5054}, doi = {}, abstract = {Eperisone Hydrochloride is a skeletal muscle relaxant and Paracetamol is cyclooxygenase inhibitor. These drugs in combination are used as antispasmodics. A simple, specific, precise and accurate method was developed, namely reverse phase high performance liquid chromatography for simultaneous estimation of Eperisone Hydrochloride and Paracetamol in tablet dosage form. In RP-HPLC method separation was achieved by HiQ silC-18HS column having 250 mm× 4.6 mm, with mobile phase containing Methanol: 0.05 mM Ammonium acetate buffer: Acetonitrile (60:30:10) and adjusted to pH 5.8 using Glacial acetic acid for RP-HPLC system. The flow rate was 1.0 ml/min and effluent was monitored at 264 nm. The retention time of EPR and PAR were 6.45 min and 3.05 min respectively. The linearity for EPR and PAR were in the range of 5-25 µg/mL. The recoveries of EPR and PAR were found in the range of 99.96-100.52% and 99.87-100.11%, respectively. The proposed method was validated as per ICH guidelines and successfully applied to the estimation of EPR and PAR in tablet dosage form.}, keywords = {Eperisone Hydrochloride,Paracetamol,RP-HPLC}, title_fa = {روش کروماتوگرافی مایع با کارآیی بالا با فاز برگشتی برای ارزیابی هم زمان اپریسون هیدروکلرید و پاراستامول در قرص}, abstract_fa = {در این کار یک روش دقیق، ساده و گزینش پذیر بنام کروماتوگرافی مایع با کارآیی بالا با فاز برگشتی برای اندازه گیری دو ترکیب دارویی اپریسون هیدروکلرید و پاراستامول توسعه یافت. رنج خطی برای این دو ترکیب عبارت بود از 25-5 میکروگرم بر میلی لیتر و بازیافت ها برای هر دو ترکیب در گستره ای بین 87/99 تا 52/100 درصد بدست آمد که نشان دهنده صحت روش حاضر در تعیین هم زمان آن در نمونه های دارویی به کاررفته می باشد}, keywords_fa = {}, url = {https://ijac.journals.pnu.ac.ir/article_1619.html}, eprint = {https://ijac.journals.pnu.ac.ir/article_1619_cf107cd254cc17b121af3ae478eb68c4.pdf} }