ORIGINAL_ARTICLE
Ion-Pair-based Dispersive Liquid Liquid Microextraction Combined with Flame Atomic Absorption Spectrometry for a Sensitive Determination of Trace Amounts of Nickel in Food Samples
In this study, a sensitive method of dispersive liquid phase microextraction based on ion-pair combined with the flame atomic absorption spectrometry was proposed for the determination of trace Ni(II) using Aliquat 336-chloride as ion pair agent. Several factors which have effect on the microextraction efficiency of Ni(II), such as pH, extraction and dispersive solvent type and their volume, concentration of the Aliquat 336-chloride, extraction time were investigated and the optimized experimental conditions were established. After extraction, the enrichment factor was 47. The detection limit of the method was 8.0 µg L-1 and the relative standard deviation for eight determinations of 100 µg L-1 Ni(II) was 2.1 %. The results for the determination of Ni(II) in food samples (black tea, lettuce, parsley and carrot) have demonstrated the accuracy, recovery and applicability of the proposed method.
https://ijac.journals.pnu.ac.ir/article_1572_28f3d7f77cfd9589fdbec14d553d7a91.pdf
2015-01-20
1
6
Ion-Pair
Dispersive Liquid Phase Microextraction
flame atomic absorption spectrometry
Ni(II)
food samples
Soleiman
Bahar
s.bahar@uok.ac.ir
1
Department of Chemistry, Faculty of Science, University of Kurdistan, P. O. Box 416, Sanandaj, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Application of Oxazolone Azo Dye Modified Alumina as New Sorbent for Separation of Palladium from Anodic Slime and Wastewater Samples
In the present work, a new kind of alumina-based adsorbent with high selectivity and stability and efficient adsorption was prepared. Alumina was coated with an oxazolone azo dye, 2-(4-{2-[4-(dimethylamino) phenyl]-1-diazenyl}phenyl)-4-[1-phenyl methylidene]-5(4H)-oxazolone, and then used for preconcentration of trace amounts of palladium. The analytical procedure involved the complex formation of Pd with oxazolone azo dye as a chelating agent in buffer media of pH 5. The stability of sorbent was excellent and adsorption capacity did not change significantly after 100 consecutive uses of 50.0 mg of modified alumina. Under the optimum conditions, the preconcentration factor of the method was 150. The linearity was maintained in the concentration range of 0.33 ng mL-1 to 8.0 mg mL-1 in the original solution. For 2.0 µg mL-1 of Pd, the relative standard deviation 1.4% and detection limit 0.25 ng mL-1 was obtained. The proposed method was successfully applied to the determination of trace amounts of palladium in the anodic slime and wastewater samples.
https://ijac.journals.pnu.ac.ir/article_1573_1f7378587b079702c840021b1981e042.pdf
2014-11-25
7
13
Modified Alumina
Oxazolone Azo Dye
Palladium
wastewater
Fatemeh
Sabermahani
fatemehsaber2003@yahoo.com
1
Department of Chemistry, Payame Noor University, P.O. Box 19395-4697 Tehran, IRAN
LEAD_AUTHOR
Tayebeh
Paykani
peikanitayebe@yahoo.com
2
Department of Chemistry, Payame Noor University, P.O. Box 19395-4697 Tehran, IRAN
AUTHOR
Samieh
Fozooni
s_fozooni@yahoo.com
3
Zarand High Education Center, Mining Engineering Department, Shahid Bahonar University, Kerman, Iran
AUTHOR
ORIGINAL_ARTICLE
Optimization of Mobile Phase of High Performance Liquid Chromatography Using Full Factorial Design for Simultaneous Estimation of Thiocolchicoside and Dexketoprofen Trometamol in Tablets
The present study was aimed to develop and validate a high performace liquid chromatography method for determination of thiocolchicoside and dexketoprofen trometamol in combined dosage form. The proposed HPLC method utilizes an Agilent Eclipse C-8 column (5 µm, 250×4.6 mm) at ambient temperature. A 23 full factorial design was performed for optimization of mobile phase for separation of two drugs. For the factorial design, the dependent variables chosen were % of acetonitrile, % of 0.1% o-phosphoric acid and pH. The optimum mobile phase consisted of acetonitrile: 0.1% o-phosphoric acid in water (41.9:58.1; pH 2.6). The flow rate was kept 1 mL/min with UV detection at 254 nm. The run time was found to be 1.41 min and 7.58 min for thiocolchicoside and dexketoprofen trometamol, respectively. The method was validated as per ICH guidelines. The calibration plots were linear in the range of 1-5 μg/mL with r2=0.998 for thiocolchicoside and 6-30 μg/mL with r2 = 0.995 for dexketoprofen trometamol. The % recovery values were found to be 98.52 ± 1.21 and 98.16 ± 1.45 for thiocolchicoside and dexketoprofen trometamol, respectively. The minimum detectable and minimum quantifiable amounts were found to be 0.11 and 0.35 μg/mL, respectively for thiocolchicoside and 1.41 and 4.38 μg/mL, respectively for dexketoprofen trometamol. The developed method could be utilized successfully in simultaneously analyzing the drugs in bulk as well as combined dosage form.
https://ijac.journals.pnu.ac.ir/article_1574_b458acdc1fb0d37ae7ec69173e72420a.pdf
2015-02-16
14
21
Thiocolchicoside
Dexketoprofen Trometamol
High Performance Liquid Chromatography
Full Factorial Design
Shivani A.
Trivedi
1
K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, India
AUTHOR
Dharati M.
Joshi
2
K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, India
AUTHOR
Samir G.
Patel
3
Ramanbhai Patel College of Pharmacy, Charusat University, Changa
AUTHOR
Rajendra K.
Patel
4
K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, India
AUTHOR
Archita J.
Patel
5
K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, India
LEAD_AUTHOR
ORIGINAL_ARTICLE
Electrochemical and Quantum Chemical Calculations of Two Schiff Bases as Inhibitor for Mild Steel Corrosion in Hydrochloric Acid Solution
The corrosion inhibition characteristics of two synthesized Schiff bases, namely N, N´-bis(2-hydroxy-6-nitrobenzaldehyde) benzidine and N, N´-bis(salysylaldehyde) benzidine, on the mild steel corrosion in 2.0 M hydrochloric acid have been investigated by weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy techniques. These studies were carried out at different concentrations, temperatures and durations. Polarization measurements indicate that the two inhibitors act as mixed type inhibitors. The adsorption of inhibitors obeys the Langmuir adsorption isotherm and the thermodynamic parameters (Ea, Kads, ΔG0ads) were calculated and discussed. Quantum chemical calculations were performed to provide further insight into the inhibition efficiencies determined experimentally.
https://ijac.journals.pnu.ac.ir/article_1582_5abcbb458ad9828d4d135b6a3540e7a3.pdf
2015-01-05
22
35
Mild steel
Schiff base
Corrosion Inhibition
Electrochemical Impedance Spectroscopy
Polarization
Nasrin
Soltani
nasrin_soltani2056@yahoo.com
1
Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, I.R. Iran
LEAD_AUTHOR
Hosein
Salavati
hosseinsalavati@yahoo.com
2
Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, I.R. Iran
AUTHOR
Mehrnoosh
Paziresh
m.paziresh@yahoo.com
3
Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, I.R. Iran
AUTHOR
A.
Moghadasi
4
Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, I.R. Iran
AUTHOR
ORIGINAL_ARTICLE
Extraction and Determination of Fexofenadine and Levocetirizine in Human Plasma by Hollow Fiber Liquid Phase Microextraction and High Performance Liquid Chromatography
A simple, inexpensive and efficient method was used for extraction and determination of Fexofenadine and Levocetirizine with three–phase hollow fiber liquid-phase microextraction and high-performance liquid chromatography. Several parameters influencing the extraction recoveries such as the nature of organic extraction solvent, pH of donor and acceptor phases, stirring rate, extraction time and salt addition to the sample solution (donor phase) were investigated and optimized. Under the optimized conditions (toluene as organic solvent, pHdonor = 2.5, pHacceptor = 12.0, stirring rate of 1000 rpm, extraction time of 30 min, with no salt addition), extraction recoveries were 64% for Fexofenadine and 79% for Levocetirizine. A good clean-up sample with excellent linearities in the range of 1–500 ng/mL for Fexofenadine (R2=0.997) and 0.6-600 ng/mlfor Levocetirizine (R2=0.998) were obtained. The limits of detection were 0.3 ng/mL for Fexofenadine and 0.2 ng/mL for Levocetirizine.
https://ijac.journals.pnu.ac.ir/article_1583_b5d984251fd729416a6cf2ca676c51d9.pdf
2015-02-05
36
42
Levocetirizine
Fexofenadine
Hollow Fiber Liquid Phase Microextraction
HPLC
Mohammadreza
Hadjmohammadi
hadjmr@umz.ac.ir
1
Department of Chemistry, University of Mazandran, Babolsar, Iran
LEAD_AUTHOR
Maede
Asadi
maedeasadi12701@gmail.com
2
Department of Chemistry, University of Mazandran, Babolsar, Iran
AUTHOR
ORIGINAL_ARTICLE
Sol-gel Approach for Fabrication of Solid-Phase Microextraction Hollow Fiber: An Efficient Adsorbent for Enrichment of Trace Levels of Antidepressant Drug, Fluoxetine
This research is on the improvement of the procedure to determination of trace levels of antidepressant drug; fluoxetine in wastewaters. In this research a silica based sol-gel was applied for the extraction of fluoxetine from water samples. This two-phase technique is consisting of aqueous samples of fluoxetine (donor phase) and silica based nanocomposite prepared by sol-gel technique (acceptor phase). Accepter phase was held in the pores and lumen of polypropylene hollow fiber segment. Microextraction experiments were carried out in two steps; extraction from analyte samples by sorbent which is held into the hollow fiber segment and desorption of drug from hallow fiber by using of methanol. Desorbed analyte in order to measurement were offered to HPLC and UV-V is spectrophotometer for further analysis. This method is simple, fast and adopted by a majority of the instrumental methods. Extraction parameters such as sol-gel aging time, pH of donor phase, volume of donor phase, extraction time, stirring rate and effect of surfactant were investigated and optimized. The measurements were done under the optimal conditions. This technique has many advantages, such as the short extraction time, low consumption of organic solvents, elimination of carry-over effect, low limit of detection and high pre-concentration factor. The pre-concentration factor and limit of detection have been gained 3227 and 0.53 ng mL-1, respectively. The linear range and relative standard deviation are 1.0-10000.0 ng mL-1 and 4.8% (n=3), respectively.
https://ijac.journals.pnu.ac.ir/article_1584_b2d1c80c8023e8295560d9a74498a452.pdf
2015-02-18
43
49
Fluoxetine
Solid Phase Microextraction
sol-gel
hollow fiber
Zarrin
Es’haghi
eshaghi@pnu.ac.ir
1
Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, I.R. Iran
LEAD_AUTHOR
Zohreh
Rezaeifar
zo_rezaeifar@yahoo.com
2
Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, I.R. Iran
AUTHOR
ORIGINAL_ARTICLE
Electrochemical Study of Some Charge-Transfer Complexes Involving Amitriptyline and Nortriptyline and Determination of Drugs
Spectrophotometric and electrochemical studies were successfully used in quantitative analysis of Amitriptyline Hydrochloride (ATH) and Nortriptyline Hydrochloride (NTH). Conductometric titration were carried out in equeous solution using iodide and dopamine and serotonine as titrant. Two new methods using spectrophotometry are dascribed for the determination of (ATH) and (NTH) with potassium bromate as the oxidizing agent and acid dyes, Methyl orange and Indigo carmine. Both spectrophotometric methods are based on the oxidation of mentioned drugs by a known excess of bromate in acid medium and in the presence of excess of bromide followed by estimation of surplus oxidant by reacting with either Indigo carmine (method A) or Methyl orange (method B) and measuring the absorbance at 609 or 507 nm.
https://ijac.journals.pnu.ac.ir/article_1585_3e7df7e958b0378a6388f6c9aa693dc6.pdf
2014-11-15
50
56
Conductometry
Amitriptyline Hydrochloride
Nortriptyline Hydrochloride
Dopamine Hydrochloride
Serotonine Hydrochloride
iodine
Azar
Bagheri Gh.
azar.bagheri@iauctb.ac.ir
1
Department of Chemistry, Center Tehran Branch, Islamic Azad University, Tehran, Iran.
LEAD_AUTHOR
ORIGINAL_ARTICLE
Reversed Phase High Performance Liquid Chromatographic Method for Simultaneous Estimation of Eperisone Hydrochloride and Paracetamol in Tablet Dosage Form
Eperisone Hydrochloride is a skeletal muscle relaxant and Paracetamol is cyclooxygenase inhibitor. These drugs in combination are used as antispasmodics. A simple, specific, precise and accurate method was developed, namely reverse phase high performance liquid chromatography for simultaneous estimation of Eperisone Hydrochloride and Paracetamol in tablet dosage form. In RP-HPLC method separation was achieved by HiQ silC-18HS column having 250 mm× 4.6 mm, with mobile phase containing Methanol: 0.05 mM Ammonium acetate buffer: Acetonitrile (60:30:10) and adjusted to pH 5.8 using Glacial acetic acid for RP-HPLC system. The flow rate was 1.0 ml/min and effluent was monitored at 264 nm. The retention time of EPR and PAR were 6.45 min and 3.05 min respectively. The linearity for EPR and PAR were in the range of 5-25 µg/mL. The recoveries of EPR and PAR were found in the range of 99.96-100.52% and 99.87-100.11%, respectively. The proposed method was validated as per ICH guidelines and successfully applied to the estimation of EPR and PAR in tablet dosage form.
https://ijac.journals.pnu.ac.ir/article_1619_cf107cd254cc17b121af3ae478eb68c4.pdf
2015-04-15
57
62
Eperisone Hydrochloride
Paracetamol
RP-HPLC
Popat
Baban Mohite
mohitepb@rediffmail.com
1
Department of Pharmaceutical Chemistry and PG Studies, M.E.S. College of Pharmacy, Sonai, Tq‐Newasa, Dist.‐Ahmednagar, Maharashtra, India‐414105.
LEAD_AUTHOR
Shantaram
Gajanan Khanage
2
Department of Pharmaceutical Chemistry and PG Studies, M.E.S. College of Pharmacy, Sonai, Tq‐Newasa, Dist.‐Ahmednagar, Maharashtra, India‐414105.
AUTHOR
Sandip
Shankar Jadhav
3
Department of Pharmaceutical Chemistry and PG Studies, M.E.S. College of Pharmacy, Sonai, Tq‐Newasa, Dist.‐Ahmednagar, Maharashtra, India‐414105.
AUTHOR