Determination of Alfuzosin, Silodosin and Naftopidil in Different Matrices - A Review

Document Type: Original research article


Department of Pharmaceutics, Mangalayatan University, Beswan, Aligarh, INDIA 202146.


Benign Prostatic Hyperplasia generally affects males above fourty years of age and has significant effect in overall quality of life (QOL). This is one of the cause of millions of dollors in healthcare expenditure. Alpha one adrenoreceptor blockers are frequently used for the benign prostatic enlargement because of their significant effect on storage and voiding symptoms, QOL, flow rate and post void residual urine volume. The present study is review on the determination of three alpha one adrenoreceptor blockers Alfuzosin, Silodosin and Naftopidil in various matrices and combinations. This kind of literature is helpful for those scientists engaged in the determination of these drugs by supporting them in terms of current available literature is one platform so that they can decide the initial conditions of their research such as decisions of mobile phase, dilutions etc. This review article also helps scientists engaged in developing formulations of these drugs.