Magnetic Solid ‒ Phase Extraction of Trace Amounts of Nickel in Food Samples Using Polydopamine Coated Fe3O4 Nanoparticles

Document Type: Original research article


1 Department of Chemistry, Payame Noor University, P.O.BOX 19395-3697 Tehran, Iran

2 . Department of Occupational Health Engineering, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran


A simple and a green methodology has been developed for the preconcentration of Ni2+ based on the adsorption of its dimethylglyoximate complex on polydopamine coated Fe3O4 nanoparticles. The adsorbed complex was easily desorbed using 1.0 mL of CHCl3 and the concentration of nickel was determined by UV-Vis spectrophotometry. The effects of pH, sorbent mass, extraction time on the sorption of nickel dimethylglyoximate complex were investigated using Box–Behnken design. In optimal experimental conditions, a wide linear range of 5.0-600.0 μg/L with detection limit of  1.49 μg/L was obtained. The proposed method was applied for extraction and preconcentration of Ni2+ in various food samples and the results were compared with the official AOAC method.



[1]     J. Zhang, J. Shao, P. Guo and Y. Huang, A simple and fast Fe3O4 magnetic nanoparticles-based dispersion solid phase extraction of Sudan dyes from food and water samples coupled with high-performance liquid chromatography, Anal. Methods 5 (2013) 2503-2510.

[2]     J.F. Liu, J. Ding, B.F. Yuan and Y.Q. Feng, Magnetic solid phase extraction coupled with in situ derivatization for the highly sensitive determination of acidic phytohormones in rice leaves by UPLC-MS/MS, Analyst 139 (2014) 5605-5613.

[3]     E. Kazemi, A.M. Haji Shabani and S. Dadfarnia, Synthesis and characterization of a nanomagnetic ion imprinted polymer for selective extraction of silver ions from aqueous samples, Microchemica Acta 182 (5) (2015) 1025-1033.

[4]     D. Huang, C. Deng and X. Zhang, Functionalized magnetic nanomaterials as solid-phase extraction adsorbents for organic pollutants in environmental analysis, Anal. Methods 6 (2014) 7130-7141.

[5]     B.D. Cai, J.X. Zhu, Q. Gao, D. Luo, B.F. Yuan and Y.Q. Feng, Rapid and high-throughput determination of endogenous cytokinins in Oryza sativa by bare Fe3O4 nanoparticles-based magnetic solid-phase extraction, J. Chromatogr. A 1340 (2014) 146-150.

[6]     J. Xu, J. Sun, Y. Wang, J. Sheng, F. Wang and M. Sun, Application of Iron Magnetic Nanoparticles in Protein Immobilization, Molecules 19 (2014) 11465.

[7]     S. Du, Z. Liao, Z. Qin, F. Zuo and X. Li, Polydopamine microparticles as redox mediators for catalytic reduction of methylene blue and rhodamine B, Catal. Commun. 72 (2015) 86-90.

[8]     Y. Ding, L.T. Weng, M. Yang, Z. Yang, X. Lu, N. Huang and Y. Leng, Insights into the Aggregation/Deposition and Structure of a Polydopamine Film, Langmuir 30 (2014) 12258-12269.

[9]     Y. Liu, K. Ai and L. Lu, Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields, Chem. Rev. 114 (2014) 5057-5115.

[10] Y. Wang, S. Wang, H. Niu, Y. Ma, T. Zeng, Y. Cai and Z. Meng, Preparation of polydopamine coated Fe3O4 nanoparticles and their application for enrichment of polycyclic aromatic hydrocarbons from environmental water samples, J. Chromatogr. A 1283 (2013) 20-26.

[11] C. McCullum, P. Tchounwou, L.S. Ding, X. Liao and Y.M. Liu, Extraction of Aflatoxins from Liquid Foodstuff Samples with Polydopamine-Coated Superparamagnetic Nanoparticles for HPLC-MS/MS Analysis, J. Agrc. Food. Chem. 62 (2014) 4261-4267.

[12] W. Chai, H. Wang, Y. Zhang and G. Ding, Preparation of polydopamine-coated magnetic nanoparticles for dispersive solid-phase extraction of water-soluble synthetic colorants in beverage samples with HPLC analysis, Talanta 149 (2016) 13-20.

[13] M. Behbahani, M. Salarian, M.M. Amini, O. Sadeghi, A. Bagheri and S. Bagheri, Application of a New Functionalized Nanoporous Silica for Simultaneous Trace Separation and Determination of Cd(II), Cu(II), Ni(II) and Pb(II) in Food and Agricultural Products, Food. Anal. Methods. 6 (2013) 1320-1329.

[14] M.A. Taher, L. Mazaheri, H. Ashkenani, A. Mohadesi and D. Afzali, Determination of Nickel in Water, Food, and Biological Samples by Electrothermal Atomic Absorption Spectrometry After Preconcentration on Modified Carbon Nanotubes, J. AOAC Int. 97 (2014) 225-231.

[15] D. Bingöl, S. Veli, S. Zor and U. Özdemir, Analysis of adsorption of reactive azo dye onto CuCl2 doped polyaniline using Box–Behnken design approach, Synth. Met. 162 (2012) 1566-1571.

[16] A. Kar, Pharmaceutical drug analysis, second ed., New Age International, New Delhi (2005).

[17] Z. Marczenko and M. Balcerzak, Separation, Preconcentration and Spectrophotometry in Inorganic Elsevier.

[18] H.L. Shi, S.L. Peng, J. Sun, Y.M. Liu, Y.T. Zhu, L.S. Qing and X. Liao, Selective extraction of berberine from Cortex Phellodendri using polydopamine-coated magnetic nanoparticles, J. Sep. Sci. 37 (2014) 704-710.

[19] M. Satake, Spectrophotometric determination of nickel and palladium by extraction of their complexes with molten naphthalene, Anal. Chemica. Acta 92 (1977) 423-427.

[20] H. Parham and S. Saeed, Pre-concentration and determination of traces of nitrobenzene and 1,3-dinitrobenzene in water samples using anthracite adsorbent, J. Ind. Eng. Chem. 20 (2014) 1003-1009.

[21] M. Satake, Spectrophotometric determination of nickel by adsorption of nickel dimethylglyoximate on naphthalene, Memoris of the Faculty of Engineering 27 (1979) 17.

[22] W. Horwitz and G.W. Lafimer, Official Methods of Analysis of AOAC International, Sections 971.20, 990.05 (2002).