Indirect Determination of Anticancer Drug Capecitabine Using Hollow Fiber Supported Multiwalled Carbon Nanotube Coated on Polyurethane Foam

Document Type: Original research article

Authors

Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Iran

Abstract

The aim of this work was indirect determination of anti-cancer drug capecitabine using complexation with platinum (IV) and determination by graphite furnace atomic absorption spectroscopy (GFAAS). For this aim at first, the complex of platinum with capecitabine was performed and the ratio of drug to metal was evalutsd with several ways. In the all of these methods, the ligand to metal ratio of the Potassium hexachloroplatinate (IV) and capecitabine complex was found to be 2:1. The extraction process was carried out by the hollow fiber supported functionalized multiwalled carbon nanotubes/ polyurethane foam (fMWCNT/PUF) foam as the solid adsorbent in the solid phase microextraction mode. The amount of desorbed platinum ion has been indirectly used to measure the drug concentrations. Parameters affecting the hollow fiber-solid phase microextraction (HF-SPME) such as pH of the donor phase, donor phase volume, the sorbent type and desorption solvent were optimized. Calibration graph was plotted and a curve with a linear response range of the 3.32 to 98.17 µg mL -1 and a detection limit 0.38 µg mL -1 was obtained.

Keywords


 

[1]     I. Amjadi, M. Rabiee and M.S. Hosseini, Anticancer Activity of Nanoparticles Based on PLGA and its Co-polymer: In-vitroEvaluation, Iran. J. Pharm. Res. 12 (2013) 623-634.

[2]     R.M. Alagar, S. Anusha,  D. Banji, K.N.V. Rao and D. Selva Kuamar, Analytical method development and validation of anticancer drugs (Imatinib and Capecitabine) by RP-HPLC method, Asian J. Res. Chem. Pharm. Sci. 3 (2015) 51 - 65.

[3]     P.R. Subbarayan, M. Sarkar, G.  Nelson, E. Benitez, S. Singhal and B. Ardalan, Chronic Exposure of Colorectal Cancer Cells in Culture to Fluoropyrimidine Analogs Induces Thymidylate Synthase and Suppresses, Anticancer. Res 30 (2010) 1149-1156.

[4]     R. Akbari and H. Akbari Javar, Efficacy of Capecitabine and 5- Fluorouracil (5-FU) on the human breast cancer cell line (MCF7) – effect of concentration, Am. J. Res. Commun 1 (2013) 75-91.

[5]     V. Rajesh, B. Anupama, V. Jagathi and P. Saipraveen, Simultaneous estimation of Gemcitabine Hydrochloride and Capecitabine Hydrochloride in combined tablet dosage form by RP-HPLC method, E-J. Chem 8 (2011) 1212-1217.

[6]     A. Morikawa, D.M. Peereboom, H.R. Thorsheim and R. Samala et al, Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study, Neuro. Oncol.  17 (2015) 289–295.

[7]     M. Meloun, Z. Ferencikova, A. Vrana A, Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data,  J. Chem. Thermodynamics 43 (2011) 930-937.

[8]     P. Singhal, P.A. Shah, J.V. Shag, P. Sharma and P.S. Sgrivastav, Determination of Capecitabine – an anticancer drug in dried blood spot by LC-ESI-MS/MS, Int. J. Pharm. Pharma. Sci 7 (2015) 238-245.

[9]     E. Piorkowska, M. Kaza, J. Fitatiuk, I. Szlaska, T. Pawinski and P.J. Rudzki, Rapid and simplified HPLC-UV method with on-line wavelengths switching for determination of capecitabine inhuman plasma, Pharmazie 69 (2014) 500-505.

[10] E.A. Mohamed, I. Ishaq and A. Abdul-Rahman, Synthesis, characterization of carbon poly urethane powder and its application for separation and spectrophotometric determination of platinum inpharmaceutical and ore samples, Talanta 121 (2014) 113-121.

[11] N. Abd-Talib, S.H. Mohd-Setapar and A.K. Khamis,  The Benefits and Limitations of Methods Development in Solid Phase Extraction: Mini Review, Jurnal Teknologi 69 (2014) 69-72.

[12] A. Zwir-Ferenc  and M. Biziuk, Solid Phase Extraction Technique – Trends, Opportunities and Applications, Polish J. Environ. Stud. 15 (2006) 677-690.

[13] Steve Zdravkovic, Solid phase extraction: Realizing the advantages of an underutilized technique, www.ppdi.com (2017).

[14] J. Vinhal, C. Lima and R. Cassella, Polyurethane foam loaded with sodiumdodecylsulfate for the extractionof 'quat' pesticides from aqueous medium: Optimization of loading conditions, Ecotoxi. Env. Safety 131 (2016) 72-101. 

[15] J. Li, B. Wang, K. Chen, X.Tian, J. Zeng, J. Xu and W. Gao, TheUse ofLignin as Cross-linker for Polyurethane Foam for Potential Application in AdsorbingMaterials, bioresources 12 (2017) 8653-8671.

[16] E.A. Moawed, N. Burham and M.F. El-Shahat, Separation and determination of iron and manganese in water using polyhydroxyl polyurethane foam, J. Assn. Arab. Univ. Basic. Appl. Sci 14 (2013) 60-66.

[17] O.S.H. Santos, M. Coelho da Silva and M.I. Yoshida, Synthesis and performance of different polyurethane foams as oil sorbents,  J. app. Polymer. Sci 134 (2017) 45409-45416.

[18] M.M. El-Bouraie, Preconcentration and determination of copper (II) and silver (I) onto polyurethane foam functionalized with salycilate, Sustain. Environ. Res 25 (2015) 171-176.

[20] D. Rosenthal, M. Ruta, R. Schlogl and L. Kiwi-Minsker, Combined XPS and TPD study of oxygen-functionalized carbon nanofibers grown on sintered metal fibers, Carbon 48 (2010) 835-1843.

[21] M.O. Ogasawara, M. Takaya and M. Yamada, Exposure Assessment of MWCNTS in Their Life Cycle, J. Phys: Conf. Series 617 (2015) 1-8.

[22] M. Deborah, A. Jawahar, T. Mathavan and M. Kumara DhasA. Milton Franklin Benial, Preparation and Characterization of Oxidized Multi-Walled Carbon Nanotubes and Glycine Functionalized Multi-Walled Carbon Nanotubes, Fullerene. Nano. Carbon. Nanostruct 23 (2015) 583-590.

[23] A. Sengupta, N. Gupta, MWCNTs based sorbents for nuclear waste management: A review,  J. Environ. Chem. Eng. 5 (2017) 5-13. 

[24] D.K. Seo, J.P. Jeun, H.B. Kim and P.H. Kang, Preparation and characterization of the carbon nanofiber mat produced from electrospun pan/lignin precursors by electron beam irradiation,  Adv. Mater. Sci 28 (2011) 31-34.

[25] F.M. Fernandes, R. Araujo, M.F. Proenca, C.J.R. Silva and M.C. Paiva, Functionalization of carbon nanofibers by a Diels Alder addition reaction, J. Nanosci. Nanotechnol 7 (2007) 3514-3518.

[26] H.H. Cho, K. Wepasnick, B. A. Smith, F. K. Bangash, D. H. Fairbrother and W. P. Ball, Sorption of Aqueous Zn [II] and Cd [II] by Multiwall Carbon Nanotubes: The Relative Roles of Oxygen-Containing Functional Groups and Graphenic Carbon, Langmuir 26 (2010) 967–981.

[27] J.D. Gelder, K.D. Gussem, P.Vandenabeele and L. Moens, Reference database of Raman spectra of biological molecules, J. Raman. Spectrosc. 38 (2007) 1133-1147.

[28] H. Sone, B. Fugetsu and S. Tanaka, Selective elimination of lead (II) ions by alginate/polyurethane composite foams, J. Hazard. Mater 162 (2009) 423-429.

[29] S.S. Kalanur, J. Seetharamappa, G.P. Mamatha, M.D. Hadagali and P.B. Kandagal, Electrochemical Behavior of an Anti-Cancer Drug at Glassy Carbon Electrode and its Determination in Pharmaceutical Formula-tions, Int. J. Electrochem. Sci. 3 (2008) 756-767.

[30] P. Ravisankar, G.D. Rao, M.N. Kumar and M.K. Chaitanya, An improved RP-HPLC method for the quantitative determination of capecitabine in bulk and pharmaceutical tablet dosage form, Der. Pharmacia. Lettre 5 (2013) 249-260.

[31] S. Hassanlou, M. Rajabi, A. Shahrasbi and M. Afshar, Development and Validation of an Ecofriendly HPLC-UV Method for Determination of Capecitabine in Human Plasma: Application to Pharmacokinetic Studies, S. Afr. J. Chem. 69 (2016) 174-179.

[32] S. Jayaseelan, S. K. Bajivali, U. Ramesh, V. Sekar, P. Perumal, Bioanalytical Method Development and Validation of Capecitabine by RP-HPLC Method, Int. J. Chem. Tech. Res. 2 (2010) 2086-2090.

[33] K. Srinivasu, J.V. Rao, N.A. Raju and K. Mukkanti, RP-HPLC Method for the Estimation of Capecitabine in Tablet Dosage Forms, Asian. J. Chem. 22 (2010) 3255-3259.

[34] K.R. Kumar, CH.M.M. Rao, CH.B. Rao, K.B.C. Sekhar and P.G. Reddy, RP-HPLC Method Development and Validation for Estimation of Capecitabine in Capsules, Int. J. Chem. Tech. Res. 2 (2010) 307-311.

[35] N.S. Rao, D. Venkataramana, P. Srinivas and P. Anitha, RP-HPLC Method for Determination of Gemcitabine Hydrochloride and Capecitabine Hydrochloride in Conbined Tablet Dosage Form,  Indo. Am. J. Pharm. Res. 4 (2014) 5134-5139.

[36] S.H. Patel and P.U. Patel, Development and validation of pH independent spectroscopic method for determination of Capecitabine, Der. Pharmacia. Sinica. 6 (2015) 19-23.