Extraction of Cetirizine Using Magnetic Nanoparticles of Hengam Island Sand and Determination by HPLC

Azad Roosta, Matina; Tamaddon, Atefeh; Moniri, Elham

doi:10.30473/ijac.2019.47181.1153

Document Type : Full research article

Authors

¹ Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran

² Department of Chemistry, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran

https://doi.org/10.30473/ijac.2019.47181.1153

Abstract

In present work Hengam island sands were used for preparation of new magnetic nano-adsorbent. These sands have intrinsic magnetic properties due to possess specific compounds such as Fe₃O₄. It was modified by surface activator agent namely 3-(Glycidyloxypropyl)trimethoxysilane to produce effective nano-adsorbent. After preparation of this nano-adsorbent, Its physical and chemical properties was verified using several techniques such as FTIR, TGA/DTG, XRD and SEM. Nano-adsorbent was used as a solid phase to extraction of cetirizine from aqueous solutions and then its determination was done by HPLC. Effective analytical parameters such as pH of sample solution (pH=4), dosage of nano-adsorbent (100 mg), zero charge (pHz=5), breakthrough volume (500 mL) and contact time (15 min) were evaluated and optimized. Furthermore, figures of merit parameters such as precision (RSD=1.44%), limit of detection (LOD=1.1 µg L^-1) and linear dynamic range (LDR=0.01-250 mg L^-1) were obtained. Also for validation the accuracy of method, amount of cetirizine in two real samples were successfully determined.

Keywords

20.1001.1.23832207.2020.7.1.2.3

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Iranian Journal of Analytical Chemistry

Extraction of Cetirizine Using Magnetic Nanoparticles of Hengam Island Sand and Determination by HPLC

References

References

Volume 7, Issue 1 - Serial Number 13
March 2020
Pages 14-20

Extraction of Cetirizine Using Magnetic Nanoparticles of Hengam Island Sand and Determination by HPLC

References

References

Volume 7, Issue 1 - Serial Number 13March 2020Pages 14-20

Volume 7, Issue 1 - Serial Number 13
March 2020
Pages 14-20