حسگرهای شیمیایی
Elham Sahebnazar; Solmaz Kia; sina Jafari Dargahlou
Abstract
Breast cancer, a significant global health concern, has seen 2.3 million new cases and 700,000 deaths in 2020. Traditional diagnostic methods, such as mammography, ultrasound, and MRI, have limitations, necessitating the development of innovative, non-invasive tools. This article explores the potential ...
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Breast cancer, a significant global health concern, has seen 2.3 million new cases and 700,000 deaths in 2020. Traditional diagnostic methods, such as mammography, ultrasound, and MRI, have limitations, necessitating the development of innovative, non-invasive tools. This article explores the potential of miRNA-based electrochemical biosensors for early detection of breast cancer, focusing on their reliability, sensitivity, selectivity, affordability, and personalized medicine. Using databases like PUBMED, Science Direct, ACS, Springerlink, Taylor & Francis, and Google Scholar, a thorough literature search was carried out in December 2025. Electrochemical biosensors and breast cancer miRNA biomarkers were the main search terms utilized, along with early-detection-related keywords. Studies were chosen for the search based on their applicability to the subject. MicroRNAs, including miR-21, miR-155, and miR-122, are effective biomarkers for breast cancer linked to tumor development and metastasis. Electrochemical biosensors, enhanced by nanotechnology, detect these miRNAs with high sensitivity and selectivity. Utilizing gold nanoparticles and graphene oxide, these biosensors enable real-time and portable diagnostics, enhancing their potential in point-of-care settings. Electrochemical biosensors based on miRNA biomarkers show promise for the early detection of breast cancer due to their high sensitivity, selectivity, and cost-effectiveness. Further research is necessary to validate their clinical efficacy and develop standardized protocols. Clinicians should stay informed about these advancements to potentially integrate them into practice, improving patient outcomes.
solmaz kia; Mozhgan Khiali; zakiyeh younesi
Abstract
Optical gene sensors are a significant advancement in biosensor technology that utilize light-based detection methods to detect specific nucleic acid sequences. These sensors utilize the principles of optics and biochemistry to achieve high accuracy and precision in the detection of genetic components, ...
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Optical gene sensors are a significant advancement in biosensor technology that utilize light-based detection methods to detect specific nucleic acid sequences. These sensors utilize the principles of optics and biochemistry to achieve high accuracy and precision in the detection of genetic components, making them valuable tools in medical diagnostics, environmental monitoring, and food safety.The main goal of this technology is to improve the accuracy and speed of gene sequence detection and use optical methods for specific detection of DNA or RNA. Optical gene sensors typically use techniques such as fluorescence, surface plasmon resonance (SPR), and absorption measurements to detect target DNA or RNA sequences. The combination of target nucleic acids and the sensor surface produces a measurable optical spot that correlates with the target. There are designs available for optical gene sensors, including fiber optic sensors, microarray platforms, and lab-on-a-chip systems. Each design offers a variety of design considerations, capabilities, and ease of use.These sensors have specific applications ranging from clinical diagnostics to the detection of genetic diseases in food products and environmental samples. Their ability to provide rapid results increases their utility in point-of-care testing scenarios.
