Abdolhamid Hatefi-Mehrjerdi; Hamid Reza Sobhi; Amir Hossein Esmaeili; Behzad Ahmadzadeh Fard
Abstract
Hydroxychloroquine (HCQ) is a widely studied therapeutic agent that has garnered significant attention for its potential applications across a range of diseases. HCQ has since been investigated for its immunomodulatory and antiviral properties, making it a candidate in the management of autoimmune disorders ...
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Hydroxychloroquine (HCQ) is a widely studied therapeutic agent that has garnered significant attention for its potential applications across a range of diseases. HCQ has since been investigated for its immunomodulatory and antiviral properties, making it a candidate in the management of autoimmune disorders as well as certain viral infections. The development of efficient electrochemical sensors for accurate HCQ measurement is crucial for clinical and pharmaceutical applications. This study presents a comprehensive comparative electrochemical investigation of glassy carbon electrode (GCE) modified with ferrocene (FC) and UiO-66-NH2 metal–organic frameworks (MOF), with and without reduced graphene oxide (rGO), for the sensitive detection of HCQ. FC and MOF incorporated with rGO to enhance their electrochemical properties. The fabricated HCQ sensor, with three wide linear ranges (1-50 nM, 50-1000 nM, and 1-100 μM), high sensitivity (0.265 μA nM−1, 0.032 μA nM−1, and 0.517 μA μM−1), and low detection limit (0.215 nM), was applied successfully for the analysis of real human blood serum and urine samples.
Abdolhamid Hatefi-Mehrjerdi; ُُSoghra Rafiei Boldaji; Mohammad Reza Yaftian; Hassan Shayani-Jam
Abstract
A novel Buprenorphine (BPR) sensor is fabricated based on nanocomposite film of benzene-1,3-disulfonate anion doped overoxidized polypyrrole/multiwalled carbon modified glassy carbon electrode. The carbon nanotubes were drop-casted on bare electrode, and then thin layer of benzene-1,3-disulfonate-doped ...
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A novel Buprenorphine (BPR) sensor is fabricated based on nanocomposite film of benzene-1,3-disulfonate anion doped overoxidized polypyrrole/multiwalled carbon modified glassy carbon electrode. The carbon nanotubes were drop-casted on bare electrode, and then thin layer of benzene-1,3-disulfonate-doped overoxidized polypyrrole formed electrochemically on it. Effect of experimental conditions involving supporting electrolyte pH, carbon nanotubes suspension drop size, and the number of potential cycles in overoxidized polymerization were optimized by monitoring the voltammetry responses of the modified electrode. Then the optimized modified electrode was used for electrochemical sensing of BPR by differential pulse voltammetry, which exhibited a linear growth with high sensitivity in anodic peak currents at the BPR concentration range of 0.06-40 µM, and a detection limit of 28 nM. Finally, the determination of BPR in urine real samples was performed by the new sensor and satisfactory results obtained.
Mohammad Ali Karimi; Abdolhamid Hatefi-Mehrjardi; Alireza Mohadesi; Sayed Zia Mohammadi; Mehdi Taghdiri; Javad Yarahmadi; Havva Mahmoodian; Shahla Nezhad Khorasani
Volume 1, Issue 1 , March 2014, , Pages 7-11
Abstract
In this work, a new, simple and fast method for the solid phase extraction-spectrophotometric determination of phosphate using cetyltrimethyl ammonium bromide immobilized on alumina-coated magnetite nanoparticles (CTAB@ACMNPs) has been developed. The determination of phosphate is based on the molybdenum ...
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In this work, a new, simple and fast method for the solid phase extraction-spectrophotometric determination of phosphate using cetyltrimethyl ammonium bromide immobilized on alumina-coated magnetite nanoparticles (CTAB@ACMNPs) has been developed. The determination of phosphate is based on the molybdenum blue method which was monitored at λmax of 810 nm. MNPs and ACMNPs characterized by SEM, VSM, and XRD spectroscopy. This method avoided the time-consuming column-passing process of loading large volume samples in traditional SPE through the rapid isolation of CTAB@ACMNPs with an adscititious magnet. Under the optimal experimental conditions, the preconcentration factor (PF), detection limit (DL), linear range (LR) and relative standard deviation (RSD) of phosphate were 80 (for 400 mL of sample solution), 0.038 µg mL−1, 0.8-10.0 µg mL−1 and 2.5 % (for 5.0 µg mL-1, n=7), respectively. The proposed method was successfully applied to the separation/preconcentration and determination of phosphate in different water samples and suitable recoveries were obtained.
