Asghar Amiri; Mohammad Rahimipour
Volume 3, Issue 1 , March 2016, , Pages 38-41
Abstract
In this research, poly (DL-lactide-co-glycolide)-block-poly (ethylene glycol), (PLGA-PEG) nanoparticles (NPs) of less than 195 nm in diameter containing of Naringenin (NRG) a naturally flavonoid were synthesized. Encapsulated form NRG improves its medical properties and solubility. The therapeutic efficacy ...
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In this research, poly (DL-lactide-co-glycolide)-block-poly (ethylene glycol), (PLGA-PEG) nanoparticles (NPs) of less than 195 nm in diameter containing of Naringenin (NRG) a naturally flavonoid were synthesized. Encapsulated form NRG improves its medical properties and solubility. The therapeutic efficacy of the encapsulated naringenin (NRG-NPs) and NRG on human lung epithelial (A549) and mouse mammary (4T1) carcinoma cells proliferation was determined by MTT assays. The cytotoxicity potency was rated as follows: NRG-NPs > NRG. The antioxidant effects of the NRG and NRG-NPs were also determined by FRAP method. Our results show that NRG-NPs are cytotoxic compounds for cancer cells and anti-cancer effect can be attributed to the presence of Fe chelatory and antioxidant effects of NRG-NPs.
Asghar Amiri; Marzieh Shabani
Volume 2, Issue 2 , September 2015, , Pages 108-111
Abstract
Recent studies have reported that metal sulfide nanoparticles had potential adverse effects. In this research, lead (II) sulfide nanoparticles have been synthesized under different reaction conditions. Scanning electron microscopy and X-ray diffraction were used to characterize the particle size ...
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Recent studies have reported that metal sulfide nanoparticles had potential adverse effects. In this research, lead (II) sulfide nanoparticles have been synthesized under different reaction conditions. Scanning electron microscopy and X-ray diffraction were used to characterize the particle size and morphology. Distribution, accumulation and toxic effects of nanoparticles on rats as a biological model were studied. Lead (II) sulfide nanoparticles (less than 50 nm in diameter) were administered orally in two doses (15 or 60 mg/Kg body weight/day) to Wister rats for 28 consecutive days. Lead concentrations and iron parameters in soft tissues were measured using inductively coupled plasma optical emission spectroscopy. The lead levels were highest in the liver, followed in decreasing order by the levels in the spleen, kidney and brain. There were no significant levels of lead in kidney and brain at low dose of administration. Iron concentration was lowest in the group that had the highest lead level, which is probably due to an interference that could take place by lead through iron uptake mechanism.
