Document Type : Review article
Authors
1 Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Ardabil, Namin, Iran.
2 Department of Biophysics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, namin, Iran.
Abstract
Optical gene sensors are a significant advancement in biosensor technology that utilize light-based detection methods to detect specific nucleic acid sequences. These sensors utilize the principles of optics and biochemistry to achieve high accuracy and precision in the detection of genetic components, making them valuable tools in medical diagnostics, environmental monitoring, and food safety.The main goal of this technology is to improve the accuracy and speed of gene sequence detection and use optical methods for specific detection of DNA or RNA. Optical gene sensors typically use techniques such as fluorescence, surface plasmon resonance (SPR), and absorption measurements to detect target DNA or RNA sequences. The combination of target nucleic acids and the sensor surface produces a measurable optical spot that correlates with the target. There are designs available for optical gene sensors, including fiber optic sensors, microarray platforms, and lab-on-a-chip systems. Each design offers a variety of design considerations, capabilities, and ease of use.These sensors have specific applications ranging from clinical diagnostics to the detection of genetic diseases in food products and environmental samples. Their ability to provide rapid results increases their utility in point-of-care testing scenarios.
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