نوع مقاله : مقاله پژوهشی کامل
نویسندگان
بخش شیمی تجزیه، دانشکده علوم، دانشگاه تبریز، تبریز، ایران
چکیده
در این پژوهش با استفاده از الکترود مغز مداد اصلاح شده با پلی(اریوکروم بلک-T) یک روش ارزان و مؤثر برای اندازهگیری ایزونیازید ارائه شدهاست. توانایی الکترود اصلاحشده در اندازه گیری الکتروشیمیایی ایزونیازید با استفاده از روشهای ولتامتری چرخهای و آمپرومتری هیدرودینامیک مورد بررسی قرار گرفته است. تعداد کل الکترونهای مبادله شده در فرآیند اکسیداسیون ایزونیازید 4 عدد به دست آمده است. مقدار ثابت نفوذ محاسبهشده برای ایزونیازید برابر با 7-10 × 74/9 سانتیمترمربع بر ثانیه میباشد. مقادیر حد تشخیص برای الکترود اصلاحشده با استفاده از روشهای ولتامتری چرخهای و آمپرومتری به ترتیب برابر با 66 میکرومولار و 4/20 میکرومولار به دست آمد. توانایی الکترود تهیه شده برای اندازهگیری ایزونیازید در نمونه حقیقی با بکارگیری الکترود جهت اندازهگیری ایزونیازید موجود در پلاسمای خون انسانی بررسی شده و نتایج حاصل با روش استاندارد اندازهگیری ایزونیازید که توسط فارماکوپه ایالات متحده ارائه شده است، مقایسه گردید. روش ارایه شده دقت مناسبی به نمایش میگذارد (%RSD=4.64). روش ارائه شده همبستگی مناسبی با روش استاندارد در سطح اطمینان 95% نشان میدهد.
کلیدواژه‌ها
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