نوع مقاله : مقاله پژوهشی کامل
نویسندگان
بخش شیمی، دانشگاه پیام نور، صندوق پستی 3697-19395 ، تهران، ایران
چکیده
هدف از این کار اندازهگیری غیر مستقیم داروی کپسیتابین به کمک تهیه کمپلکس آن با یون پلاتین (IV) و اندازهگیری آن با اسپکترومتری جذب اتمی با کوره گرافیتی است. به این منظور ابتدا کمپلکس کپسیتابین و یون پلاتینیوم تهیه شد و نسبت دارو به فلز با روشهای مختلف تعیین گردید. در همه روشها مشخص شد که نسبت لیگاند به فلز برای کپسیتابین و پتاسیم هگزاکلروپلاتینات(IV) 2:1 میباشد. فرآیند استخراج توسط فیبر متخلخل حمایتشده با فوم پلی اورتان/ نانولوله چند دیواره عاملدار به عنوان جاذب جامد با سبک میکرواستخراج فاز جامد انجام شد. مقدار یون پلاتینیوم واجذب شده بصورت غیر مستقیم برای اندازهگیری غلظت دارو مورد استفاده قرار گرفت. پارامترهای موثر بر روش میکرواستخراج فاز جامد فیبر متخلخل مانند pH فاز دهنده، حجم فاز دهنده، نوع جاذب و حلال واجذبی بهینه شدند. منحنی کالیبراسیون رسم شد و محدوده خطی 32/3 تا 17/98 میکروگرم بر میلیلیتر با حد تشخیص 38/0 میکروگرم بر میلیلیتر بدست آمد. در نهایت روش برای تشخیص و اندازهگیری داروی ضد سرطان کپسیتابین در نمونههای حقیقی به کار برده شد.
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