Iranian Journal of Analytical Chemistry

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Determination of Mesalazine Using Ion Mobility Spectrometry in Pharmaceutical Samples

Document Type : Full research article

Authors

1 Department of Chemistry, Ya.C., Islamic Azad University, Yazd, Iran

2 IAU, Yazd branchDepartment of Chemistry, Ya.C., Islamic Azad University, Yazd, Iran

Abstract

Ion mobility spectrometry is an analytical technique with main advantages such as high sensitivity, fast response and simplicity. The purpose of this work was to determine of mesalazine in different pharmaceutical samples using ion mobility spectrometry with a positive corona ionization source. After obtaining the best instrumental parameters (injection temperature: 230 ºC, cell temperature: 180 ºC, drift voltage: 6800 V, corona voltage: 2400 V, flow rate of drift gas: 600 mL/min and flow rate of carrier gas: 300 mL/min) the linear dynamic range was 1.0–70.0 ng with a determination coefficient, R2=0.9881. The relative standard deviation values were lower than 6.0% (n=5) for the examined range (10.0–60.0 ng) of the drug. The limit of detection and limit of quantitation were 0.3 ng and 1.0 ng, respectively. The capability of the developed method was evaluated for the determination of mesalazine in tablet, capsule, and suppository as pharmaceutical samples. Satisfactory recovery results were obtained in the range of 98.0–103.8%.

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References
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Iranian Journal of Analytical Chemistry
Volume 12, Issue 2
February 2026
Pages 52-59
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