Document Type : Full research article

Authors

• Arash Mohammadinejad ¹
• Mahmoud Ebrahimi ¹
• Ali Morsali ¹
• Zarrin Es’haghi ²
• Hamed Chegini ¹
• Abdolhossein Ebrahimitalab ¹

¹ Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran

² Department of Chemistry, Faculty of Sciences, Payame Noor University, PO Box 19395-3697, Tehran, Iran

Abstract

 
In this work, a carbon paste electrode modified with multiwall carbon nanotubes (MWCNTPE) was used for the sensitive voltammetric determination of acetaminophen (AC) in biological and pharmaceutical samples. The electrochemical behavior of acetaminophen was investigated employing cyclic voltammetry. It was revealed that the standard electrode potential of half reaction for AC(O), H+/AC(R) was 0.898 V. under the optimized experimental conditions, the oxidation peak current for acetaminophen was found to vary linearly with concentration range of 0.12 to 99 µM with detection limit of 0.06 µM using differential pulse voltammetry. DFT-B3LYP/6-31G (d,p) and HF/6-31G (d,p) calculations were performed for deoxidized acetaminophen (AC(R)) and its oxidized form (AC(O)). The calculated standard electrode potentials are relatively in agreement with experimental data. This electrode  was employed for determination of acetaminophen in hospital waste water, hair, blood and pharmaceutical samples considering its high sensitivity, low detection limit, good reproducibility and its non-existent interference at trace levels in clinical and quality control laboratories.
 

Keywords

• Acetaminophen
• Differential pulse voltammetry
• cyclic voltammetry
• Multiwall Carbon Nanotubes